Overview
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MashFrame® Pharmacology Suite (MF-Pharm) is a highly
interactive and secured solution for management of pharmacokinetic /
pharmacodynamic (PK/PD) data, analysis and reports. It provides
capability to integrate with multiple commercial and open source
applications on different platforms (Windows or Linux), used for PK/PD
data collection, analysis and reporting needs.
MF-Pharm provides capabilities to support automated…
- Data import/export
- Data validations
- Data review and preparation
- PK/PD analyses (NCA, POP-PK, Simulations, etc.)
- PK/PD Reporting
MF-Pharm was developed to provide a flexible and scalable
pharmacology platform with open API’s so that PK Scientists can freely
use multiple applications (open source or commercial) in a compliant,
secure and seamless environment.
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MF-Pharm comes with ready to use out of the box...
- Over 75 configurable objects with…
- 46 objects for PK/PD data management and preparation
- 10 objects for PK/PD reporting
- Over 45 widgets for interactive user interfaces
- Objects for multiple platforms (Unix/Windows)
- Open API to create and add custom objects
MF-Pharm also provides 21 CFR part 11 compliance with audit trailed
tracking of data, analysis & reports. And MF-Pharm’s architecture
natively supports cloud based computations.
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Features
MF-Pharm provides following high level
capabilities:
Automated
importing, validation and diagnostic reporting of analytical laboratory data from multiple Laboratory Information Management Systems (LIMS) and data
files (like Excel, CSV, SAS, XML, Etc.)
Automated
importing, validation and diagnostic reporting of clinical data from multiple clinical data
system (like Oracle Clinical) and data files (like Excel,
CSV, SAS, XML, Etc.) |
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Interactive workflow to view, explore, validate and prepare
PK/PD data in real time |
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| Secured
and compliant platform to seamlessly integrate & use
multiple open source and commercial PK/PD applications |
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Simple
and intuitive user interface with ready to use out-of-the box
over 75 PK/PD specific configurable
objects/components.
Open API to create and add custom objects. |
Standard Objects Examples
- Data Input (Files, Databases, Repositories & Web Services)
- Data Output (Files, Databases, Web Services, Emails &
Repositories)
- Data Visualizations (Tables, Charts, Open Source and
Commercial Tools)
- Data Validation
- Data Merging
- Data Sub-setting
- Data Normalization
- BLQ Adjustments
- Running R Scripts
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Built-in PK/PD analysis suite
with Plasma and Urine PK Parameters.
- 50+ Parameters
- Configurable user interface
- Kel Start and Stop Time points UI
- AUC Trapezoidal Calculation Rules
Open APIs to integrated with other
commercial/enterprise desktop or server based analysis applications.
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Standard Parameters
- Cmax, Tmax, Cmin, Tmin, CLast, TLast, TLag, Kel, Kel_R_Sqr,
Kel_R_Sqr_Adjusted, THalf, KelTimeStart, KelTimeEnd,Kel_C_0,
Kel_Number_Points, AUC_All, AUC_Last, AUC_Infinite,
AUC_Interval, AUMC_Infinite, MRT_Last, CLF, VZF, VSS
- Urine Parameters
- AT, AE, AE_Total, Volume_Sum
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Built-in PK/PD reporting capability
(Tables, Listings and Charts).
Open APIs to integrated with other commercial/enterprise desktop
or server based reporting applications
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| Easy to use and compliant application features
to exchange data and reports with any commercial or enterprise application.
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Full audit trail capability. With simple interface
to review, report and compare records for internal or
regulatory audits. |
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Screenshots
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| Application dashboard showing study status, rss feeds,
links to team documents and shortcut to recently created
analysis and datasets |
Analysis workflow showing drilldown
on a time point for flagging (exclude from analysis) |
Application interface
showing a widget for
reviewing analytical and CRF data |
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| Application workspace showing interface to browse Projects,
Studies, Datasets, Analysis and Reports |
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Examples
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Interactive and modular framework for validation,
preparation, and exploration of data collected
for
model-based meta-analysis of Young Maniac Rating Scale in
bipolar patients. |
PK/PD
Data Exclusion Flags Widget |
Preview
of Bio-Analytical data (AUC profile on Day 1 of a subject) |
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Previewing concentration data in a data grid widget
with controls to filter and subset data in real-time. |
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Downloads
We are pleased to make evaluation copy of MashFrame® Pharmacology Suite 2.0 (Desktop), available for download so that you may evaluate this software on your system before making a purchase decision.
Click here to register for evaluation copy download.
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