High Performance Computing (HPC) Infrastructure

High-performance computing continues to change the way modeling and simulations are done. Our mission at Rudraya is to help your organization prosper in this new computing economy. High-performance computing or HPC simply refers to the use of supercomputers and computer clusters to solve advanced problems involving complex and/or large-scale computation (like NONMEM runs).

Historically, high-performance computers have been mostly used by supercomputing centers in well-funded universities. But HPC today is not just for the nation's largest supercomputing facilities. With new advances in processing and clustering software technology, even an organization of modest size can afford and benefit from an HPC system of computer clusters.

By leveraging our domain and business expertise, we provide infrastructure development services to create HPC solutions for Modeling and Simulation needs.

  • Robust hardware infrastructure
  • Implement commercial and open source software
  • Traceability
  • NONMEM runs automation
  • Web-based interface to manage NONMEM runs
  • Multiple users and locations supported
  • NONMEM Run Summaries and Plots

Analysis and Application Tools

NONMEM

R

FORTRAN COMPILER

  • NONMEM ® is a nonlinear mixed effects modeling tool used in population pharmacokinetic / pharmacodynamic analysis
  • NONMEM ® 7.2 is programmed in Fortran 90/95 code
  • Requires a Fortran 90/95-compliant compiler
  • Some NONMEM ® runs can take considerable time, perhaps many hours or even days, depending on the speed of the computer and the size of the problem.
  • Software environment for statistical computing and graphics
  • Preparing analysis ready data (PK, PK/PD, PD)
  • Summarizing data (Table and Graphs)
  • Intel ® Fortran Composer XE 2011 for Linux
  • Includes Intel ® Fortran Compiler, Intel ® Math Kernel Library
  • Required to compile NONMEM code

ORACLE GRID ENGINE

Xpose

PsN

  • Oracle Grid Engine software is a distributed resource management (DRM) system that manages the distribution of users' workloads to available compute resources.
  • When users submit their work to Oracle Grid Engine as jobs, the software monitors the current state of all resources in the cluster and is able to assign these jobs to the best-suited resources.
  • Xpose is an R-based model building aid for population analysis using NONMEM.
  • It facilitates data set checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison.
  • Perl-speaks-NONMEM (PsN) is a collection of Perl modules
  • Aiding in the development of non-linear mixed effect models using NONMEM
  • Parameter estimate extraction from output files
  • Data file sub setting and resampling
  • Advanced computer-intensive statistical methods.

Architecture

Security and Compliance

Best Practices

  • Secure Data Repository
  • Study Level Access
  • Regulatory Compliant
  • Validated Environment
  • Standard Operating Procedures
  • Active Directory
  • Firewall
  • Virtual Private Network
  • Standardized Project / Study Structure
  • Standardized Model Files
  • Standardized Reports
  • Standardized Naming Conventions

Supported Technologies


Pharmacometrics Tools

Workload Management Tools

Operating Systems

Fortran Compilers

Multiple Message Passing (MPI) Libraries

NONMEM
PsN
R
Xpose
PDx-Pop
Census
Wings
S-Plus
Subversion
Pirana
IBM Platform LSF
Sun Grid Engine
MashFrame NM
Pcluster
Mosix
Red Hat
SUSE
CentOS
Scientific Linux
Debian
Ubuntu
GCC G77
G95
GFORTRAN
Intel Fortran
MPICH2
MVAPICH
MVAPICH2
OpenMPI

Our Expertise

 
 
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Affiliation and Accreditation

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